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KMID : 0882419970520030334
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Korean Journal of Medicine
1997 Volume.52 No. 3 p.334 ~ p.342
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Lipoprotein ( a ) Levels Relate to Vascular Complications in Patients with Non - Insulin - Dependent Diabetes Mellitus ( NIDDM )
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Kim Seon-Hee
Chae Hee-Bok
Park Joong-Yeol
Min Won-Ki
Kim Woo-Kun
Kim Ghi-Su
Lee Ki-Up
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Abstract
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Objective : High serum Lp(a) concentration is associated with a high risk of coronary artery disease(CAD). This study was initiated to determine whether increased Lp(a) levels are associated with diabetic vascular complications in Korean patients with NIDDM.
Methods : A total of 183 NDDM patients were studied cross-sectionally for the presence of various vascular complications. Lp(a) levels were measured by 1-step sandwich ELISA method.
Results : The patients with overt proteinuria had higher Lp(a) levels than the patients with mormoalbuminuria or microalbuminuria(26.8mg/dl vs 13.8 mg/dl and 17.3mg/dl, p<0.05), The patients with proliferative retinopathy and/or those treated by photocoagulation had higher Lp(a) levels than those without retinopathy or those with background retinopathy(34.1mg/dl vs 13.3mg/dl and 16,9mg/dl, p<0.05), The Lp(a) levels were also higher in the patients with CAD than those without CAD(30.9mg/ dl vs 16.3mg/dl, p<0.05). Multiple logistic regression analysis revealed that high Lp(a) levels were independantly associated with CAD and severe diabetic retinopath3.
Conclusion : High Lp(a) levels are associated with CAD and proliferative retinopathy in Korean patients with NIDDM.
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